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Pratham began working in the state of Karnataka in 2002. Some key programmes include:
Read India is active in 13 blocks across 6 districts.
Urban Learning Centers as part of the Read India urban programme are active in Mysore implementing pre-school, primary, upper primary interventions, Library and out of School Children.
Special Programmes
ITC funding a special programme called 'Read India Plus' which reaches out to children in pre-school till Std. 8. This is active in 2 locations across the state.

Pratham Mysore joined hands with Soften, the Corporate Social Responsibility team at Infosys, to launch the 'Nurture Merit' programme. This project aims to impact the lives of children from economically weaker sections who show potential based on merit. Students passing the grade 10 examination with over 70% marks are financially supported to further their education. So far, over 120 students have benefited from this initiative.

  Knowledge Bridge:
A list of subjects and questions from groups of students who are looking for knowledge, information and improving their skills is collected by Pratham Mysore. These questions are made available to the volunteers who wish to provide answers. A volunteer can select any subject of his or her choice and prepare in a manner that will be understood by students in the age group of 10-15 years.
All efforts must be made to make the subject non-technical and easy to understand. The volunteer is responsible for collecting all data on the subject, preparing models, charts, diagrams, presentations, videos etc.
  Innovative Series:
Innovative series is a unique program under Pratham Mysore which has the main objective to nurture the potential of the Government school children in different areas of learning and bring them to the forefront of competitive excellence.
Objective: Implementing novel methods of teaching and learning to foster thinking skills and trigger the levels of motivation and self-confidence in Government school children
Under this series, 14 different programs have taken place so far like summer camps and remedial programs, benefiting many children by giving an access to quality education. With a content specifically designed by Dr. Padmini.T, Director - Academic Program and Trustee of Pratham Mysore, innovative series has come a long way to cater specific needs of the children.
Government Tie Ups
National Means-cum-Merit Scholarship Scheme (NMMSS) is a Central Government sponsored scheme with the objective of awarding scholarships to meritorious students of economically weaker sections. This also acts as a preventive measure to stop students from dropping out of school. With help from Pratham, 5 schools are covered in this programme in Mysore city reaching over 300 children.