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Pratham began working in the state of Maharashtra in 1994. Some key programmes include:
Read India is active in 17 blocks across 11 districts.
The Urban Programme is active in 10 cities across the state. These are - Mumbai, Aurangabad, Nagpur, Nashik, Navi Mumbai, Pimpri Chinchwad, , Solapur, Thane, Pune and Jalgaon.
The Second Chance programme is present at 6 locations across Nandurbar, Satara, Solapur, Nagpur, Pune, and Alibag and reaches 1,000 drop-out students annually.
Multiple Early Childhood Care and Education initiatives are underway in various locations in urban as well as rural Maharashtra.
Science fairs and workshops are active in a few locations across the state as part of Pratham's Science programme.
An English Programme is active in Mumbai and Thane, and it is also a part of other urban programs as a subject.
Under Pratham's Vocational Training programme there are Hospitality Training Centres in Aurangabad, Ralegaon and Satara; Construction Training Centres in Latur and Ahmednagar; an Electrical Training Centre in Talasari; Bedside Assistance Training Centres in Latur, Nashik, Chembur, and Baramati; Automotive Training Centres in Kolhapur and Panvel; a Godrej Beauty Hub in Thane; Tailoring Centres in Talasari and Latur; a Multi-Skilling Entrepreneurs Centre in Pune; and General Skilling Centres in Chembur and Satara.
Pratham Council for Vulnerable Children interventions began in 2001 in the state and today are being implemented in Jalgaon, Aurangabad, Mumbai and Nandurbar.
Special Programmes
Pratham Supported Schools are operational in 4 blocks in Maharashtra.
ITC Ltd. is funding a special programme called 'Read India Plus' which reaches out to children in pre-school till grade 8. This is operational in Pune.
Bharat Petroleum Corporation Limited funds a programme with Pratham in the Nandurbar district for children in primary and upper primary government schools.
Government Tie Ups
In 2003, Pratham collaborated with the government of Maharashtra for the Janshala programme to be implemented in Thane district. Through this programme, Pratham trained school teachers on its Learn to Read programme. Janshala was a United Nations-Government of India joint programme to improve the quality of education of children in India.

In June 2013, Pratham further collaborated with MSCERT through a USAID sponsored project in 3 blocks in 3 districts of Maharashtra. The aim was to help children to not only read fluently but also to listen, speak, comprehend and write on their own. This collaboration oriented 675 school teachers across 450 schools.

A partnership with MSCERT also exists to train and support primary school teachers across the state in delivering a remedial programme for Std. 2-5, focusing on reading and basic arithmetic. The programme was piloted in all Marathi medium schools across 36 districts.